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PAR-15-175: Phenotypic and Functional Studies on FOXO3 …

Sep, 24th 2017 6:55 am, Article Recommended by Dr. J. Smith

Department of Health and Human ServicesPart 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

National Institute on Aging (NIA)

Funding Opportunity Title

Phenotypic and Functional Studies on FOXO3 Human Longevity Variants to Inform Potential Therapeutic Target Identification Research (R01)

Activity Code

R01 Research Project Grant

Related Notices

Funding Opportunity Announcement (FOA) Number

Companion Funding Opportunity

Catalog of Federal Domestic Assistance (CFDA) Number(s)

Funding Opportunity Purpose

The focus of this Funding Opportunity Announcement (FOA) is on in vivo human studies, and in vitro studies on human cells or tissues, aimed at potential identification of therapeutic targets or and/or testing of interventions for healthy aging. Potential therapeutic targets include FOXO3 itself and upstream and downstream regulators in pathways mediated by FOXO3. The range of research areas of interest in this FOA includes studies that: 1) examine in vivo phenotypic effects of human FOXO3 variants, and/or 2) elucidate effects of these variants on cellular functions and the pathways that mediate them, and/or 3) identify and evaluate candidate therapeutic targets (e.g., target validation studies, testing of candidate compounds) for potential interventions based on FOXO3 functional pathways.

Projects involving whole genome sequencing of new or existing cohorts are outside the scope of this FOA. However, targeted resequencing on a limited sample set in an existing cohort could be supported by this FOA.

Key Dates

Open Date (Earliest Submission Date)

Letter of Intent Due Date(s)

Application Due Date(s)

Standard dates apply, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Standard AIDS dates apply, by 5:00 PM local time of applicant organization. All types of AIDS and AIDS-related applications allowed for this funding opportunity announcement are due on these dates.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance toall requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applicationsthat do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Table of Contents

Part 1. Overview InformationPart 2. Full Text of the Announcement

Section I. Funding Opportunity DescriptionSection II. Award InformationSection III. Eligibility InformationSection IV. Application and Submission InformationSection V. Application Review InformationSection VI. Award Administration InformationSection VII. Agency ContactsSection VIII. Other Information

Background

There has been growing interest in identifying genetic influences on healthy aging in the development of novel strategies to increase human health span. Human genetic variants associated with longevity are also associated with reduced risk for many, though not all, age-related diseases. In this regard variants in the FOXO3 gene, part of the mammalian forkhead-box (FOXO) gene family of transcription factors, have been found to be associated with longevity in multiple populations and with lower prevalence of stroke, coronary heart disease and cancer. Interestingly, studies have also reported that the coding variants of the FOXO3A gene may not be key players in human aging and longevity associated SNPs in FOXO3A are located in the intronic regions of the gene. However, these polymorphisms have largely been explored in case-control studies and not much progress has been made to uncover their functions and mechanisms for the identification of functional relevant SNP(s). The introns of a gene contains downstream regulatory elements which ultimately affects the gene regulation and signaling including post transcriptional modifications, and in this way the overall expression level as well as pattern of expression of the gene get affected. Intronic variants could also serve as enhancers that could possibly enhance the expression of many genes.

FOXO3 influences multiple cellular pathways, and differences in expression of FOXO3 have been associated with a variety of cellular and physiologic effects, including effects on mechanisms hypothesized to affect rates of aging changes. Yet little is known about the physiologic and molecular factors modulating the favorable effects of the FOXO3 longevity variants on health span. Mechanisms of cellular quality control have recently been found to be involved in longevity and could play an important role in mediating the ability of FOXO to extend lifespan and delay signs of age-related diseases. In general the FOXO proteins are believed to orchestrate various cellular functions through a complex network of interactions with different transcription factors and cofactors. The FOXO proteins are also subject to multiple levels of regulation via post-translational modifications (PTMs) including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FOXO family proteins, their half-lives, DNA binding properties, transcriptional activity and interactions with other cellular proteins.

New insights into the relationships of FOXO3 longevity variants to specific exceptional survival endophenotypes (e.g. delayed age of onset of a specific disease, potential differential effects on FOXO expression in individuals with FOXO3 longevity variants versus non-longevity variants) as well as, elucidation of the molecular mechanisms underlying the physiological effects of such variants could avail considerable opportunities for the discovery of novel therapeutics/clinical interventions (e.g., novel candidate compounds or existing drugs which mimic protective effects) to promote healthy aging. Assessing the potential for drugs or other interventions which could mimic these favorable effects requires evaluation of potential therapeutic targets as well as evidence-based selection of candidate interventions for preliminary testing in in vitro systems, animal models, or humans. Such target identification and selection of candidate interventions could be informed by greater understanding of differences between FOXO3 longevity variants and other FOXO3 alleles in their relationships to:

Research Objectives

The focus of this FOA is on in vivo human studies, and in vitro studies on human cells or tissues, aimed at potential identification of therapeutic targets or and/or testing of interventions for healthy aging. Potential therapeutic targets include FOXO3 itself and upstream and downstream regulators in pathways mediated by FOXO3. The range of research areas of interest in this FOA includes studies that: 1) examine in vivo phenotypic effects of human FOXO3 variants, and/or 2) elucidate effects of these variants on cellular functions and the pathways that mediate them, and/or 3) identify and evaluate candidate therapeutic targets (e.g., target validation studies, testing of candidate compounds) for potential interventions based on FOXO3 functional pathways.

Examples of potential research strategies to address the research objectives include, but are not limited to:

For all the above, consideration of potential differences in phenotypic and functional effects to age and tissue differences, and to gene-environmental actions (e.g., response to stressors) is encouraged.

Research projects of interest include, but are not limited to:

For ancillary studies using data from established cohort studies, applicants are responsible for adhering to the individual study policies governing ancillary projects and access to clinical trials data and/or biorepository samples.

Funding Instrument

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New Renewal Resubmission Revision

The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets are not limited but need to reflect the actual needs of the proposed project.

Award Project Period

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

1. Eligible Applicants

Eligible Organizations

Higher Education Institutions

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Governments

Other

Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicant Organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time. This means that the NIH will not accept:

Section IV. Application and Submission Information

1. Requesting an Application Package

Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.gov.

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.

Page Limitations

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.

SF424(R&R) Cover

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Project/Performance Site Locations

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Other Project Information

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Senior/Key Person Profile

All instructions in the SF424 (R&R) Application Guide must be followed.

R&R or Modular Budget

All instructions in the SF424 (R&R) Application Guide must be followed.

R&R Subaward Budget

All instructions in the SF424 (R&R) Application Guide must be followed.

PHS 398 Cover Page Supplement

All instructions in the SF424 (R&R) Application Guide must be followed.

PHS 398 Research Plan

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

Letters of Support: The application should include a letter of support from the relevant study committee granting access to data sets and/or repository (if application involves analysis of stored samples) and approval of the proposed secondary analysis study.

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PAR-15-175: Phenotypic and Functional Studies on FOXO3 …

HGH Injections | Nutropin AQ (somatropin) injection, for …

Sep, 24th 2017 6:53 am, Article Recommended by Dr. J. Smith

IMPORTANT SAFETY INFORMATION Nutropin therapy and your safety:

Please read this Important Safety Information carefully. Then, if you have any questions, talk with your doctor.

What should you tell your doctor before starting Nutropin therapy?

While taking Nutropin, contact your doctor immediately if you experience:

Other important information about Nutropin

What are common possible side effects of Nutropin therapy?

Common side effects reported in adults and children taking Nutropin therapy include injection site reactions. Additional common side effects in adults include swelling, joint pain, and carpal tunnel syndrome.

You may report side effects to FDA at (800) FDA-1088 or http://www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

How should you store Nutropin?

Nutropin must be kept refrigerated (36 to 46F [2 to 8C]). Do not freeze. Cartridges and NuSpin pens must be used within 28 days of initial use. Throw away any unused Nutropin after 28 days of initial use. Before giving an injection, check the manufacturers expiration date on the cartridge or pen. Do not use if it has expired. Do not inject medication if the solution is cloudy.

Please see accompanying Nutropin full Prescribing Information for additional Important Safety Information.

Nutropin AQ (somatropin) injection for subcutaneous use is a human growth hormone that is available by prescription only.

Doctors prescribe Nutropin therapy for children and teenagers who are short or growing slowly because they:

Doctors prescribe Nutropin therapy for adults who have growth hormone deficiency that began either in:

Your doctor will test to see if growth hormone is right for you.

Follow this link:
HGH Injections | Nutropin AQ (somatropin) injection, for …

Sermorelin Weight Loss – Benefits of Sermorelin HGH injections

Sep, 22nd 2017 10:51 pm, Article Recommended by Dr. J. Smith

Weight gain due to human growth hormone decline can be difficult to manage, but there is an answer through Sermorelin Weight Loss. Sermorelin is a drug that first appeared in the 1970s, and it has become the more natural solution to managing a human growth hormone (HGH) deficiency. Instead of replacing the HGH in the event of a problematic deficiency, this remarkable medication encourages the pituitary gland to begin producing more of its own growth hormone. Before any medication can be prescribed by the highly skilled doctors of Kingsberg Medical, the patient must be evaluated. The doctor must decide that this treatment program will be safe and effective before it will be prescribed. Weight loss is only one of the many benefits of Sermorelin HGH injections. If you feel encumbered by excess weight and worry that an HGH deficiency is starting to get the best of you, it is time to take the first step to contact one of the professionals at Kingsberg Medical to receive an evaluation for a prescription for Sermorelin injections!

As you start to look into this incredibly effective treatment program, you will find that the benefits of Sermorelin HGH injections are numerous. As the Sermorelin works with your body and begins to assist it in increasing the amount of HGH produced, you will start to notice your health improving in many various ways. Once sluggish metabolism begins to increase, and more energy and stamina is the welcomed result. When our patients begin to experience the joy of waking up in the morning and exuberance for moving around, they find one of the most highly anticipated benefits includes excess weight loss. The simple answer to the question Is Sermorelin good for weight loss is simply yes. Sermorelin is not prescribed specifically for weight loss. It is prescribed only for those who have been found deficient in growth hormone production. However, reversing this downward spiral can result in a healthier body and more youthful attitude and outlook on life. Metabolism is a natural process that our body has to break down the food we consume into the energy we use every day. Although metabolism and weight loss dont go hand in hand, they do affect each other greatly. The better your metabolism is working the better your body can process food and stored fat, and turn it into energy.

For many, an extremely important question they should be asking themselves is, other than losing weight what other benefits can I expect from Sermorelin therapy? Simply gaining weight is not the only negative and debilitating effect of a human growth hormone deficiency. The other benefits from Sermorelin therapy include an increase in energy and stamina, improved bone density, heightened libido, and even improved muscle mass. Many times the health issues caused by a HGH deficiency are brushed off as simply getting older, but that is not the case. The reason you cant keep up with your kids on the play ground, or you just arent keeping up with the younger people at work is because of the decrease in human growth hormone. Knowing how to get a prescription for Sermorelin HGH is an important first step in a process to getting you back into your prime! In the US, the only legal route to get Sermorelin is through a doctor who can evaluate your particular circumstances and write a prescription such as our doctors here at Kingsberg Medical.

Occasionally, when one finds out that Sermorelin increases the production of human growth hormone, they ask questions such as Is Sermorelin Good for Weight Loss? The simple answer to this question is yes, but of course there is more behind it than that. As Sermorelin increases the amount of growth hormone produced, it affects the body and begins to reverse the negative impact of a growth hormone deficiency. In the end result, your body is still receiving more HGH than it originally had. This increase is the key to improving ones health and creating a positive physical environment in the body. Sermorelin and weight loss results very often go hand in hand. When you begin to take therapeutic Sermorelin injections, many people find that their excess weight will slowly begin to fall away before you know it, you will be enjoying the abundant energy which accompanies a healthy weight and body size. Because using Sermorelin is a more natural process, the body fat will not disappear overnight, but will go gradually and more naturally, as well.

In working with the doctors at Kingsberg Medical, you can be confident to get the right Sermorelin dosage for weight loss. However, this will also provide the added bonus of generally increasing ones overall health! The best start is to fill out the contact form which can be found on every page on our website. Once we receive the form, one of our trusted medical advisors will contact you and explain the details of the evaluation process. The physician in charge will determine the optimum Sermorelin dosage to correct human growth hormone deficit. From there, our pharmacy will prepare your prescription to be sent directly to your door. Once you receive the complete package with your medication and all the necessary items for self administering the medication, you will start to see your concern Is it possible to lose weight with Sermorelin is something not to worry about at all. The physicians of Kingsberg Medical are very experienced with prescribing the correct dosages for every individual that they encounter and treat. Before you know it, you will find yourself not only losing weight but reaping the other benefits that occur with the use of injectable Sermorelin.

Gaining and losing fat is a very individual process, and predicting each individuals Sermorelin and weight loss results isnt feasible. When first starting the treatment, growth hormone levels do not increase as rapidly as they would if direct supplementation was utilized. Sometimes this leaves men and women questioning their results. One might wonder if this is this the right treatment? The question is normally yes, but if ones growth hormone level has declined to a significantly low level, then a bit of a boost may be needed. Doctors may prescribe Sermorelin along with human growth hormone replacement therapy injections. When these two work together, much quicker results can be achieved. The combination of this powerful HGH replacement therapy and the correct Sermorelin Dosage for weight loss can help people achieve their goals on a more satisfying time line. The combination of these medications is a safe and reliable way to help the body get back to its top performance. At times, using this combination synergistic therapy helps men and woman avoid being on either program for an extended amount of time leaving them with more time and money to do what is important with their newly discovered energy and stamina.

Because Sermorelin is a drug that works differently from most types of injectable hormone therapies, patients often submit inquiries such as Is it possible to lose weight with Sermorelin, and Is Sermorelin as effective as bioidentical HGH injections? These are questions that our doctors answer all of the time and their answer is, of course! Although Sermorelin works differently than the normal HGH injections, they still work just as well. The major difference between the two is just the time frame that they work. Sermorelin works by encouraging the pituitary gland to produce more Human Growth Hormone over time. This is a much more natural and gradual way of increasing the amount of HGH in the body. Sermorelin weight loss is just as effective as any other program on the market, but it still depends on the individuals commitment to make it work. The body still has an increase of human growth hormone, and therefore is still has many of the same benefits. Many people like Sermorelin because the body is producing the necessary hormones itself, but also because they have the opportunity to use both Sermorelin and a name brand doctor prescribed human growth hormone replacement therapy at the same time. This is a powerful combination that gives you the instant results from a HGH injection which also has longer lasting results from the pituitary gland producing its own growth hormone.

What many do not know is that the ability to buy HGH Sermorelin injections isnt as clear as many websites advertise it to be. When you are in the market for any variety of HGH injections you need to make sure that you are working with a clinic that is not going to put your health in danger and your money at risk of being wasted. Many websites advertise that you can buy Sermorelin without any kind of prescription. This is what causes the confusion for many people. This information is simply not true. To receive any kind of injectable Sermorelin, which is the only effective medication, you must have a doctors prescription and receive the drug through a regulated US pharmacy. Instead of wondering where to buy Sermorelin, you should be asking yourself where to find a doctor who can prescribe Sermorelin HGH injections. Kingsberg Medical is one of those places! Contact us using any of the forms on this page, and we will guide you through the process to determine if Sermorelin is safe for you. We will examine your blood work and also decide which dosage is going to work the best with your body and your life style. This is one of the best ways to assure that you are receiving safe and effective amounts of injectable Sermorelin.

After learning about all of the benefits of Sermorelin HGH injections, many people start to wonder where to find a doctor who can prescribe Sermorelin HGH injections. Since you have come across this page, this is the perfect start! The doctors here at Kingsberg Medical are extremely skilled and well versed on how the body works with Sermorelin, and they know what the best dose is for you to be receiving. Local doctors and medical advisors will work with you during the time that you need them the most. One of the most noticeable returns in using prescription Sermorelin injections is weight loss, and because of that doctors often get the question other than losing weight what other benefits can I expect from Sermorelin therapy? There are an abundance of benefits from Sermorelin therapy to say the least. These include other improvements to your body such as a decrease in fat, cellulite, cholesterol, wrinkles and an increase in muscle mass. Also there are many results that you do not see in the mirror, but you will feel them quite clearly, including decrease in feeling sluggish, mild depression, fatigue and mental fogginess. Often there is also an increase in sex drive, energy level and a quicker recovery from injury and illness.

The internet has made getting the process of how to get prescription for Sermorelin HGH easier and safer than ever before. To get a prescription you must first need one due to a Growth Hormone deficiency, and this must be confirmed by our doctors evaluation. The dosage and process for prescribing Sermorelin is a little different than other injectable growth hormone. The prescription is prescribed in micro grams (MCG) and is also based on different health criteria. The most common dosage for both men and women tends to be 200 MCG. In most cases, this is the optimal amount of Sermorelin that is needed to get ones body back into shape. When you buy HGH Sermorelin injections, you need to make sure that you are receiving them from a US government authorized pharmacy and using a doctors prescription. When you consult Kingsberg Medical, the process is simple.

Originally posted here:
Sermorelin Weight Loss – Benefits of Sermorelin HGH injections

Choices Weight Management

Sep, 22nd 2017 1:54 am, Article Recommended by Dr. J. Smith

Choices Weight Management

Are you exercising? Decreasing your calories? STILL not losing weight? We can help!

Our program has been very successful in treating overweight patients with PCOS, Type II Diabetes, thyroid conditions, and etc.

Our program is for all who are attempting to achieve a healthy body weight.

Our metabolic vitamin injection is a unique combination of B vitamins.

Body Mass Index provides a reliable indicator of body fatness for most people.

We are thrilled to announce the opening of our medical nutrition practice, with a special focus on Bariatric and Functional Medicine via an evidence-based, individualized approach.

Choices Weight Management goes beyond conventional weight loss methods, specializing in addressing weight loss resistance through the treatment of:

Our Medical Director, Dr. Josephine Brown, has 20 years of experience in Family and Bariatric Medicine. The term bariatric derived from the greek word, bari, meaning weight. Bariatric medicine is the art and science of medical weight management.

We believe that obesity is a disease and we treat it as such through individualized meal plans, lab testing, supplementation, and FDA approved appetite suppressants based on our clients medical history and preference. Regular private office visits with body fat analysis are provided.

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Choices Weight Management

How Quickly Can You Expect to Lose Weight When You Eat a …

Sep, 22nd 2017 1:53 am, Article Recommended by Dr. J. Smith

This is one of those questions that gets asked a lot so I wanted to address it in this post.

I know that one of the things that excited me about starting the ketogenic diet in the beginning was reading about all these crazy weight loss success stories that some women seemed to experience. You know, the ones where they lose 14 pounds in the first three weeks and then continue to lose 4 pounds a week for the next 6 months and voila theyre at their ideal weight.

I loved the thought of getting into a fat burning state and just watching the excess pounds melt away.

In actuality, it took me about a year to lose 30 pounds. However it didnt take a year for me to start feeling and looking a great deal better, though. This actually happened in a matter of weeks.

The thing about losing weight on the keto diet is every woman is different. Those who have a lot of excess fat will find that it comes off more quickly. Those who have a lot of metabolic derangement or hormonal healing to do will find that it takes longer.

Your bodys main goal is always survival and health. It doesnt care about how it looks, it cares about how its functioning.

When you start eating keto with weight loss in mind, you kind of have to trust the process. What you are doing is feeding your body all the nutrients it needs to heal, build, release and do whatever it needs to do in order to move towards optimal health. Some women will experience this as a fairly drastic weight loss, and others will experience this as a slow weight loss.

If you have a great deal of healing and balancing to do internally, you may even experience a little weight gain in the beginning. (I know, few women want to hear this).

Embarking on a journey of health is a little like embarking on a journey of trust and faith. You give your body what it needs and you trust that it has the intrinsic knowledge (which it does), to do what is necessary.

The ketogenic diet is not a fad diet, its a lifestyle of health. And one of the most common things I hear from women who have embarked on this journey is that they learn so much about their bodies and their minds along the way.

With that being said, here are the most common weight loss patterns that I have heard women experience when eating keto:

Out of all the weight loss scenarios Ive heard of, the most common one by far is where women get despondent because they feel like they are not losing weight fast enough. And they are completely disregarding other things that are happening that indicate their health and well-being is increasing.For example, better sleep, more energy, clearer skin, higher libido, more regular and easier menstruation, and even inches lost.

With my journey, you know when I was happiest? It was when I stopped weighing or measuring myself at all and trusted my body and the keto process.

I realised that if I hadnt lost weight one week, it meant that my body was doing something else equally (if not more) important, and it was all good.

Its not all about the number on the scale far from it.

I highly encourage every woman these days to let go of weighing and measuring and instead focus on health, well-being and nourishing body, mind, and soul. When you do this, you can be sure that your body will happily reach the perfect weight for you at exactly the time its supposed to.

I hope this is helpful, as always Id love to hear any comments below!

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How Quickly Can You Expect to Lose Weight When You Eat a …

25 of the worlds top Diets That Work reviewed Plus health …

Sep, 20th 2017 6:48 pm, Article Recommended by Dr. J. Smith

Diets That Work For Maximum Weight Loss

Diets that work are something that many health and weight-conscious people are searching for. These kinds of programs are often called fad diets. Most fad diets can help you lose a few pounds quickly, but they might not work in the long term, as some health problems could arise. These health issues occur because of very low caloric intake or the diet plans are not well balanced. Diets that work for weight loss are often overwhelming. This is because many people focus on losing weight and do not provide their bodies with all the essential vitamins and nutrients. A good diet plan that truly works can help you lose weight without draining your health and energy.

In the past, weve been bombarded with a lot of diets. But are there diets that really work? The simple answer is yes. Being on a diet isnt all bad news. There are many diets that can help you lose weight while allowing you to eat what you love.

To start with, losing weight is not as easy as most people tend to think. Well, it takes more time to lose weight than it takes to gain the same amount of weight. So are low-calorie diet plans the best option? Or is it better to restrict carbs?

Experts agree that no matter what diet plan you decide to follow low calorie, low fat, or low carb, etc. it doesnt matter. The most important thing is to stick to your chosen diet plan. Most researchers that evaluate the success rates of various diet plans or low-fat diets evaluate the weight loss just for a short period of time. When experts have carried out research studies on diets, they have realized that dieters who followed the diets lost the same amounts of weight.

And this explains why so many people fail in their efforts to lose weight long term. Any diets that ask you not to eat a whole category of food (particularly a food category as important as carbs) are certainly asking you to slip up.

The key to long-term, constant weight loss, and more importantly, getting in shape and maintaining a healthy body is developing a diet plan that supplies your body with all the essential nutrients and vitamins you need while also providing you with a chance to enjoy those foods that you hold dear to your heart. Leading a healthy lifestyle should be your main goal, as that is what will help you to lose and maintain a healthy weight.

however the temptation of all those cakes, sweets and fatty foods who would want to scrimp and scrape on their calories. Cutting your calories to 1500 for a female and 2000 a day for a male will help you lose at least a pound of fat per week. The reason being for this is that a calorie deficiency of 3500 a week will allow you to shed the fat.

Diets that work is a widely researched and sought after topic, causing debates and controversy around the world.

There are so many ridiculously unbelievable diets to the totally pointless ones. However, there are a select few that do get great results too.

The way to identify if a diet plan is healthy is to check if you look bright and vibrant. Diet plans that make you tired and irritated will never work because starving yourself will only make you fall ill. Healthy diets that work consist of all the nutrients that are necessary for the body to function normally. Following a good diet plan and exercising for at least 15 minutes a day will effectively work towards losing weight.

Diets that work is a major topic of discussion nowadays, with many studies carried out over the years. There are so many useless diets that can only make the situation worse. However, there are some that deliver the desired results in a great way. A good way to determine whether a diet works is to find out if you look cheerful while following it. Diet programs that make you bored and annoyed will never work simply because starving yourself can lead you to sickness and ultimately, an unhealthy body.

Your body image matters a lot. It matters because if you feel comfortable about your body, it makes a huge difference in developing a positive body image and also plays a major role in promoting a good body image for other people as well. The fashion industry may assume that we are one size, one shape, but when it comes to losing weight, it is not a one size fits all kind of plan. No two people are the same and for that matter, you need a diet plan that is designed to help you meet your individual needs.

Theres no diet plan that will work for everyone. Also, there is no miracle diet that will cause you to drop those excess pounds while you are asleep. Creating a diet plan that supplies your body with the nutrients, vitamins, and enjoyment that you need is the best way to achieve success. This is because, at the end of the day, no one wants to be on a diet for life.

Make sure you eat high-quality foods. You will notice the difference and therefore, you will eat less since tasty food is full of flavor! As a result, weight loss will be an enjoyable journey. This is particularly important when it comes to fruits and vegetables. Make sure you buy organic foods as much as possible.

You can order it from a natural foods store and have them delivered straight to your doorstep. Not only are fresh fruits and vegetables so delicious, but they are also very healthy. Buying organic foods doesnt have to cost a fortune. You should focus on eating well, eating less and wasting less in the process.

There are several tried and tested diets that work effectively to burn fat and lose weight. The diets that work results may vary depending on each persons body and health conditions. It is important to drink at least 6 to 8 glasses of water every day to flush out toxins from the body. Following any of these diet plans with a combination of easy exercises like walking, brisk walking or slow jogging will provide great results. Diet plans work better if alcohol, sugar, and excess spices are avoided. Consult a physician before starting any diet plan.

No matter what proven diets that work you chose to follow, you will always wish that you could be on this one or that you could just eat what you want as you promise to eat healthily. Dont trust yourself. This one never works, it amazes me how many times I go on a diet and mentally punish myself saying why did I have to eat this or how did I manage to become so big? You take all delicious food for granted until you begin a diet regime. If only I could have put that cake down, if only I felt as guilty before it as after I ate it and then maybe I wouldnt have eaten it. Too little too late Im afraid, once that cake has digested the only place that cake is going is on your hips, stomach, and thighs. Its true what they say, a moment on the lips is a lifetime on the hips. If only this statement was as false as some of these crazy fad diets.

Enjoying your food is the key to building a healthy relationship with food. Here are some important tips to help you develop a healthy diet plan.

Know your metabolism type: no two individuals are the same, so dont expect one diet to suit everyone. Know your metabolism type and stick to a meal plan that suits your health and fitness goals.

Go organic: as weve mentioned earlier, it is important to choose organic foods and cut on processed foods. Prepackaged or processed foods are packed with preservatives and many other chemicals that are designed to prolong their lifespan on the shelves. The end result is that they hinder the proper functioning of various body processes, including digestion, and might end up causing weight gain.

Exercise: medical experts are almost unanimous that physical exercises are vital to the proper functioning of the human body. In addition to eating well, you need to exercise regularly in order to lose weight and maintain a healthy body.

So which diets work fast? The fact is that no one really knows how many diets really work. This is because there are plenty of diets being developed or reinvented that all of us have lost track of them. You will also find some diets with the same regime but under different names. It is not possible to keep track of them all.

So we have compelled a list of some of the top diets that work for you.

Therefore, it is important to consider those diets that recommend making healthy dietary and lifestyle changes. If you think dieting is the best option for you, then you need to choose a good diet that suits your dietary preferences, your lifestyle, and schedule. Whether it be;

The low carb diet:This is one of the most common diets that work for people who wish to lose weight. Excess carbohydrates in the body can lead to imbalanced insulin levels which lead to obesity. An easy way to follow a no carb diet is to avoid all white foods. Sugar, white rice, white flour, pasta, white bread, potatoes and many other white foods contain carbohydrates that need to be avoided. Low carb diet should ideally contain good protein sources like tuna, eggs, chicken breasts and turkey. Vegetables like mushroom, cucumber, lettuce, spinach, carrots are low in carbohydrates. []

The Raw food diet: This diet consists of foods that are not cooked or processed. Raw foods contain enzymes that help in quick digestion and ensure optimal health. When foods are cooked or processed, these enzymes die out. The raw food diet is usually a vegan diet that consists of fresh vegetables, fruits, and nuts. Sprouts, carrots, tomatoes, coconut milk, raisins, almonds, oranges, apples, pine apples, etc can be consumed. Honey can be added to sweeten fruit juices. Raw eggs, cheese, raw milk can be included for a non-vegan raw food diet. []

The volumetric diet:This is one of the most favorite weight loss diets that work as it focuses on eating low-calorie foods that can give a feeling of fullness. People who love to eat a lot, but willing to lose weight should follow the volumetric diet. Fruits and vegetables contain low calories so they can be consumed in large amounts to satiate the appetite. Pasta, breakfast cereal, salad dressings, non starchy vegetables, low fat meat like fish and chicken, legumes, beans and eggs, water rich vegetables like cabbage give a feeling of fullness but are low in calories can be included in the volumetric diet. []

Zone diet:The zone diet is an ideal diet for people who wish to lose weight gradually without feeling tired or worn out. The diet contains carbohydrates, proteins and fat in a balanced ratio of 40:30:30. People have the freedom to eat whatever they want but in a balanced amount. The diet helps in maintaining a stable insulin level which causes weight loss gradually but keeps the energy levels high. The zone diet is followed by many dieticians and celebrities around the world thats why it is know as one of the diets that work as it supplies the body with all essential nutrients in a balanced ratio. []

The 3 day diet:The three day diet is one of the popular diets that work among run way models and cardiac patients. Patients are given the three day diet to lose weight quickly before their cardiac surgery. Models love this diet as it helps them lose up to ten pounds in 3 days. This is however an unhealthy diet so it advised to be followed only for 3days. The diet consists of limited tuna, eggs, grape fruit, lean meat and vegetables. Only salt and pepper should be used to season the foods and sugar is strictly not allowed. It is very important to consume 8 liters of water per day while following this diet. After 3 days, the dieter must gradually get back to their normal diet. []

Flat belly diet:This is another favorite diet among dieters as it helps in losing belly fat within a month. The diet consists of 2 parts: anti bloat jump start and 4 week diet plan. The anti bloat jump start reduces and prevents bloating and helps in weight loss quickly. Foods that cause bloating and gas (cabbage, onions, coffee, sugar, tea and soda) must be completely avoided. The key foods in the 4 week diet plan are fish, fruits, vegetables and olive oil. The plan includes four 400 calorie meals per day. []

The Atkins diet:Dr Robert Atkins was the founder of this diet. The Atkins is more than certainly a proven one of the diets that work. Within The Atkins eating regime its all about counting carbs. You will eventually have your body burning body fat as its main energy source rather than carbs you eat. Within this there are 3 separate phases Induction/ongoing weight loss and lifetime maintenance. This diet was followed by Kim Kardashian in order to help her lose her post baby weight. []

Fast Diet/5:2 Diet/Fasting Diet:No it doesnt mean that this diet works fast. It means that you need to fast on it. Well when I say fast, it means 500/600 kcal per day, well when I say per day I mean for 2 days and these 2 days must be spread throughout the week. You will eat as you please for 5 days and for the remaining 2 days you will have to almost fast. []

Dash Diet:The Dash Diet has been voted one of the best and healthiest diets. It lessens your risk of hypertension and heart attacks. Would you like to live for longer? Well the Dash Diet will help, that statement doesnt come with a warranty sadly. However The Dash Diet is based upon the diet of a Mediterranean person who tends to live like 3 years longer. Give it a go, its one for all the family to join in and do together. []

Weight Watchers:The increasingly popular weight watchers regime. In this diet you need to initially get weighed and then you will be given your daily/activity/weekly points. Every single food and beverage will have a value of points in it. You total up your points throughout the day and dont go over. []

Thats just a select few diets that are listed. Remember which ever diet you end up sticking to for 1 day to the whole diet, you need to be positive that it is the right one for you to be on at that time. Think of all your dietary requirements as well as when you have time to eat. This will help you decide what to do whether it be following in Kim Kardashians footsteps and choosing the Atkins or counting points on the Weight Watchers.

Remember to always seek medical advice on this subject.

Drinking warm water first thing in the morning will boost metabolism and help in weight loss. Mixing honey and cinnamon to warm water is very good for cardiovascular health and weight loss. It burns unnecessary fat and enhances blood circulation. Drinking hot water after every big meal aids digestion and prevents fat from storing in the abdominal area. Sedentary lifestyle is one of the main reasons for obesity. It is important to fill your day with gentle exercises like walking up and down the stairs instead of using an elevator, jogging in place while watching TV and walking in circles while listening to music. Eating everything in moderation and exercising regularly is the key to stay healthy and fit.

visit all our diets we have on our diets that work website that is updated regularly

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25 of the worlds top Diets That Work reviewed Plus health …

PA-14-316: Obesity and Asthma: Awareness and Self …

Sep, 20th 2017 6:45 pm, Article Recommended by Dr. J. Smith

Department of Health and Human Services Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

National Institute of Nursing Research (NINR)

Funding Opportunity Title

Obesity and Asthma: Awareness and Self- Management (R01)

Activity Code

R01 Research Project Grant

Related Notices

Funding Opportunity Announcement (FOA) Number

Companion Funding Opportunity

Catalog of Federal Domestic Assistance (CFDA) Number(s)

Funding Opportunity Purpose

The purpose of this funding opportunity announcement is to stimulate research to examine the relationship between asthma, obesity and self-management. The prevalence of both asthma and obesity has significantly risen in the past few decades. Although the association between these two conditions has been found in many studies, the exact mechanisms for how this association arises are unresolved to include self-management and achieving control. Because both of these conditions have their beginnings in early life, an aspect of the association between them that requires more understanding is their common exposures in early life and transition into adulthood. Studies that investigate the molecular pathways linking asthma and obesity are encouraged as long as the studies describe how this relates to self-management. In addition, intervention studies targeting asthma or obesity and their effects on each other, and possible mechanisms of action and effect on behavior, are encouraged.

Key Dates

Open Date (Earliest Submission Date)

Letter of Intent Due Date(s)

Application Due Date(s)

Standard dates apply, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Expiration Date

New Date January 8, 2018 per issuance of NOT-NR-17-011. (Original Expiration Date: September 8, 2017)

Required Application Instructions

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance toall requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applicationsthat do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Table of Contents

Part 1. Overview InformationPart 2. Full Text of the AnnouncementSection I. Funding Opportunity DescriptionSection II. Award InformationSection III. Eligibility InformationSection IV. Application and Submission InformationSection V. Application Review InformationSection VI. Award Administration InformationSection VII. Agency ContactsSection VIII. Other Information

Purpose

The purpose of this funding opportunity announcement is to stimulate research to examine the relationship between asthma, obesity and self-management. The prevalence of both asthma and obesity has significantly risen in the past few decades. Although the association between these two conditions has been found in many studies, the exact mechanisms for how this association arises are unresolved to include self-management and achieving control. Because both of these conditions have their beginnings in early life, an aspect of the association between them that requires more understanding is their common exposures in early life and transition into adulthood. Studies that investigate the molecular pathways linking asthma and obesity are encouraged as long as the studies describe how this relates to self-management. In addition, intervention studies targeting asthma or obesity and their effects on each other, and possible mechanisms of action and effect on behavior, are encouraged.

Background

Asthma is a chronic condition involving the respiratory system in which the airways intermittently constrict, become inflamed, and are lined with excessive amounts of mucus, often in response to one or more triggers. Examples of triggers of asthma include upper respiratory infections, allergens (house dust mites, cockroach, pollens, molds, and animal epithelials), exercise, and cold air. Epidemiologic studies suggest there is a dose-effect relationship between weight and asthma. In the adult, co-morbidities of diseases associated with obesity (e.g., dyslippidemia, gastroesophageal reflux disease (GERD), and sleep-disordered breathing) may provoke or worsen asthma. Both asthma and obesity are considered inflammatory conditions. These relationships suggest that obesity and asthma may share a common etiology. Further understanding of the mechanistic basis for the relationship between obesity and asthma may lead to new therapeutic strategies for treatment in these populations.

In 2012, current asthma prevalence in the United States was 8.2%, affecting 25.5 million people (18.7 million adults and 6.8 million children aged 017 years). Asthma attack prevalencethe proportion of the population with at least one attack in the previous yearwas 4.2%. The most rapid growth in asthma prevalence occurred from 1980 to 1996, when asthma prevalence grew from 3.5% to 5.5%.

Significant differences in current asthma prevalence exist between many population subgroups in the US. Higher rates exist among females, children, non-Hispanic black and Puerto Rican persons, those with family income below the poverty level, and those residing in the Northeast and Midwest United States. Asthma can involve costs related to health care use and morbidity, including missed work and school days. Even after accounting for prevalence differences between groups, health care use differs among groups. Non-Hispanic black persons have relatively low rates of ambulatory visits compared with their use of urgent health care services, which may represent underuse of preventive services or non-availability of them. Although children have higher health care use than adults, they have much lower death rates. However, because adverse asthma outcomes, including death, are largely preventable, lowering asthma morbidity and mortality rates among people of all ages remains a priority. The large asthma burden and continued adverse outcomes present an ongoing public health challenge, including the effort to enhance uptake of underutilized management strategies to control symptoms.

Obese individuals comprise 34% of the adult population 20 years and older living in the United States. Obese adults are more likely to report poor asthma-specific quality of life, poor asthma control, and an increase in asthma-related hospitalizations compared to non-obese individuals. Studies show a relationship between increased body mass index and asthma. Increased body mass index has a stronger association with asthma in women than in men. Over the past decade, obesity has become recognized as a national health threat and a major public health challenge. In 20072008, based on measured weights and heights, approximately 72.5 million adults in the United States were obese (CDC, 2010). Obese adults are at increased risk for many serious health conditions, including coronary heart disease, hypertension, stroke, type 2 diabetes, certain types of cancer, asthma, and premature death. Healthy People 2010 identified overweight and obesity as 1 of 10 leading health indicators and called for a reduction in the population of children and adolescents who are overweight or obese. However, the United States has not made progress toward that target goal. Overweight and obesity rates in children and teens have risen significantly. From 1976-1980 until 2003-2004, obesity rates in children and teens tripled (17.1% are currently obese), and rates in overweight children almost doubled from 9.1% to 16.5%.

This will affect self-management recommendations. Previous research focusing on altering dietary habits and physical activity behavior has targeted individuals and not families. These interventions have been generally unsuccessful in establishing long-term behavior changes. A number of environmental influences spanning community, societal, national, and international environments are correlated with an increased prevalence of obesity. These include increased portion sizes, school food and physical activity environments, the built environment (such as sidewalks and street design), the community food environment, high costs of fresh produce and lean meats and fish. Other factors are technological advances leading to reduced requirements for physical activity at work and at home, developments in agriculture and food technology leading to decreased costs of processed food and food products, and marketing of high-calorie foods, especially to children.

Many studies have supported the link between asthma and obesity. Although the evidence favors an association between asthma and obesity, the exact nature of the association remains unclear as well as its management. Also, whether the increase in prevalence of obesity has led to the increase in asthma prevalence remains controversial. Because both of these conditions have their beginnings in early life an aspect of the relationship between obesity and asthma and self- management in early life and the transition to adulthood needs to be explored.

Scope

The areas of interest for this announcement could include, but are not limited to:

Funding Instrument

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New Renewal Resubmission

The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets are not limited but need to reflect the actual needs of the proposed project.

Award Project Period

The scope of the proposed project should determine the project period. The maximum period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

1. Eligible Applicants

Eligible Organizations

Higher Education Institutions

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Governments

Other

Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicant Organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time. This means that the NIH will not accept:

In addition, the NIH will not accept a resubmission (A1) application that is submitted later than 37 months after submission of the new (A0) application that it follows. The NIH will accept submission:

1. Requesting an Application Package

Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.gov.

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.

Page Limitations

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.

SF424(R&R) Cover

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Project/Performance Site Locations

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Other Project Information

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Senior/Key Person Profile

All instructions in the SF424 (R&R) Application Guide must be followed.

R&R or Modular Budget

All instructions in the SF424 (R&R) Application Guide must be followed.

R&R Subaward Budget

All instructions in the SF424 (R&R) Application Guide must be followed.

PHS 398 Cover Page Supplement

All instructions in the SF424 (R&R) Application Guide must be followed.

PHS 398 Research Plan

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the SF424 (R&R) Application Guide, with the following modification:

Appendix: Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.

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PA-14-316: Obesity and Asthma: Awareness and Self …

College Student Borrows Notebook From Parents, Makes Emotional Discovery – HuffPost

Sep, 7th 2017 11:45 pm, Article Recommended by Dr. J. Smith

Before her sophomore year of college, Hailey Weiss grabbed an old notebook from her parents home to use throughout the school year. She soon learned that the notebook had significant meaning for her parents before she was even born.

Hailey went through old school supplies at her parents house at the suggestion of her mother, Carrie Weiss. Carrie didnt realize that the borrowed notebook was the same one she had used while she and her husband, Jeff, faced infertilitywhen trying to start a family.

A few days after Hailey arrived at the College of New Jersey, she learned the notebooks previous purpose when she discovered a gestation calculator wheel in one of its pockets, a separate calendar that showed dates between 1995 and 1997 and her mothers handwriting on pockets labeled referrals, prescriptions and questions.

The notebook Im using for college helped you guys keep track of creating me! (Pretty sure), Hailey texted her mom and dad.

You are my miracle, her mom later replied.

Read their conversation below.

Carrie told HuffPost she cleaned out the notebook years ago, keeping the important medical records and putting sentimental things like ultrasound photos in family keepsake boxes. She said she must have missed the gestation calculator wheel.

Carrie and Jeff turned to intrauterine insemination (IUI) and human chorionic gonadotropin (HCG) so she could become pregnant. They have been open with Hailey about their past infertility struggles, but she was still surprised to find actual evidence of that time in their lives in the notebook.

Carrie and Jeff also have a son. After welcoming Hailey, they tried the same strategy so Carrie could become pregnant again, but after she was diagnosed with an anxiety disorder, she and Jeff agreed the process was taking a toll on her. Thats when the couple decided to adopt, at least until Carrie was surprised to learn she was pregnant.

We had the paperwork [for adopting] on the counter and the checkbook, and I wasnt feeling well, she told HuffPost. I said, Let me just check. And we got really lucky a second time.

Carrie posted her text conversation with her daughter in a Facebook group called Grown and Flown Parents. She has since received feedback from people who shared that they know what its like to experience infertility struggles.

When we went through all that infertility stuff years ago we didnt have Facebook and social media so you didnt know how many people were going through the same thing, Carrie told HuffPost. [After I posted], everyone just chimed in and said, Me, too.

When asked if she had any advice for other people having trouble becoming pregnant, she said she never lost hope that she would one day have a family.

I always just felt like whatever route its going to take Im going to find my family, she said. And families come in all different shapes and sizes and forms, and I truly believe that if people pursue family for the sake of having a family that they will find it.

Talking about the process with her daughter, sharing the texts online and receiving support from others has been a full-circle moment for Carrie.

Im kind of getting that closure that there were people going through what I was going through, and it wasnt that different, she said. And to me, it just kind of put it all to rest, but I didnt realize I really even needed it.

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College Student Borrows Notebook From Parents, Makes Emotional Discovery – HuffPost

Kate Middleton Is Struggling With Hyperemesis Gravidarum Again – SheKnows.com

Sep, 7th 2017 11:45 pm, Article Recommended by Dr. J. Smith

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Three things the Queen of England does not want us to think about:

Don’t worry about the corgis, Your Majesty. (Sorry, but we just don’t care.) That said, royal reproduction has definitely been on our minds ever since Kensington Palace tweeted on Sept. 3 that Kate and William are indeed expecting their third child.

The duchess is early in her first trimester so why the official announcement so soon with the risk of miscarriage still uncertain? Well, the folks at the palace made the decision share the news before it hit the media via whispery Reddit sub-threads since poor Kate is once again suffering from hyperemesis gravidarum,the violent and rare version of morning sickness that incapacitated her during her first two pregnancies. In fact, the duchess was already too sick to make a scheduled engagement on Sept. 4.

“Morning sickness” is an innocuous and misleading term in many cases, including Kate’s. Regular old morning sickness affects up to 80 percent of pregnant women and would likely befit our favorite elegant AF duchess much more nicely than hyperemesis gravidarum, its far more sinister and unrelenting cousin.

One could spring back from morning sickness via a delicate dab of the mouth with a monogrammed handkerchief and maybe a swish of mouthwash served in a tiny silver cup. But hyperemesis gravidarum, which only occurs in about 2 percent of pregnancies, is marked by vomiting so intense and unremitting that sufferers are often hospitalized for IV fluid and nutrition therapy as Kate was while pregnant with Prince George. (It’s possible she was also hospitalized for the same condition while pregnant with Princess Charlotte, but that remains unconfirmed.)

More: People Are Actually Shaming Kate Middleton for Her Third Pregnancy WTF

Dr. Sherry Ross, a Santa Monica OB-GYN, and Dr. Jaime Knopman, a reproductive endocrinologist in New York City, spoke with Us Weekly about hyperemesis gravidarum and how and why it may be affecting Kate.

Persistent nausea and vomiting can become so severe that moms lose weight and become malnourished and dehydrated… In these situations, hospitalization, intravenous hydration, and nutrition are needed,” said Ross. Eating and drinking is a nightmare… Women suffering from HG can feel depleted, exhausted and depressed.

So if even the Duchess of Cambridge is susceptible to this debilitating condition, obviously so are we normals. So what are the risk factors? Is there anything a woman can do to avoid HG?

Knopman has little good news for us on that front, unfortunately. HG is pretty much out of a mom-to-be’s control. And it can but doesn’t always attack the same poor women during more than one pregnancy. Usually women who get it once are more likely to get it again, she said.Risk factors include a personal or family history of HG… and a history of motion sickness or migraines.

And if you’re expecting twins, triplets or more, well, buckle up. Mothers-to-be who are preparing for multiples are at higher risk for HG, possibly due to higher levels of human chorionic gonadotropin, the pregnancy hormone wreaking havoc in the body like a drunken freshman frat boy desperately trying to steamroll his way off campus.

There is a little bit of good news about HG, according to Knopman. If HG is monitored and the mother receives good medical treatment, she might actually be at lower risk for miscarriage. The thinking is that the higher hCG levels indicate a healthy and robust placenta,” Knopman said. “The better the placenta, the better the chance that the pregnancy will progress.

Well, if anybody has a robust placenta, it’s probably Kate. (We imagine it’s shaped like a limited-edition Prada purse.)

When will our dear duchess be out and about again in her signature nude hose and heels doing wonderful charity work and coaxing George and Charlotte in and out of private jets, you ask? Ross said HG can stick around until 20 weeks (*gulp*) of pregnancy or even longer.It tends to improve in the last half of pregnancy but may persist until delivery,” Ross said.

Kate’s doctors are likely recommending the same things Ross recommends to her nonroyal HG patients: bananas, rice, applesauce and toast (the BRAT diet, which is neither Wisconsin bratwurst nor connotes any brattiness on Kate’s part), along with ice-cold, fizzy beverages in teeny-tiny sips. No red-hot curries, super-salty foods or gigantic portions of protein. Vitamin B6, ginger and acupressure and acupuncture are also put to use whether or not they actually work by many HG sufferers seeking natural remedies.

Just close your eyes, sip your cool, carbonated ginger beverage, and think of England, Kate. We’re rooting for you.

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Kate Middleton Is Struggling With Hyperemesis Gravidarum Again – SheKnows.com

Pregnancy Detection Kits Market with Worldwide Industry Analysis to … – LANews By Abhishek Budholiya (press release) (blog)

Sep, 7th 2017 11:45 pm, Article Recommended by Dr. J. Smith

Pregnancy test kits are used for an early indication of pregnancy. Home pregnancy tests are easy to use, inexpensive, and provide results in a few minutes. Most at-home pregnancy test provide 97% to 99% accurate results when used as per instructions.

A urine pregnancy kit is used to detect human chorionic gonadotropin (hCG) hormone, a special hormone that is produced only in a pregnant womans body. hCG production increases in the early days of pregnancy with its level doubling every 2 to 3 days in the blood. The presence of hCG above a particular range confirms pregnancy.

The global pregnancy detection kits can be divided by product type, end-user, type of test, and region.

The publication on the global pregnancy detection kits market makes for an interesting read due to its many offerings. This includes projections of the various segments and sub-segments based on their past and current performance. With the help of standard industry tools such as SWOT analysis and Porters Five Forces, the report provides a value chain analysis and market attractiveness analysis until the end of the forecast perioid in 2024.

Increasing awareness about the availability of pregnancy detection kits, rising awareness about the utilization of self-detecting pregnancy kits and their benefits, and the increasing demand for self-detecting pregnancy kits are the major factors boosting the global market for pregnancy detection kits. Moreover, the rising adolescent pregnancy rate, promotional campaigns undertaken by manufacturers that engage celebrities to influence rural population for the utilization of pregnancy testing devices, technological advancements in pregnancy kits, and expansion of distribution network of product manufacturers for widespread availability of kits.

However, high cost of pregnancy detection kits, which makes it unaffordable in undeveloped and developing countries is a major constraint to the markets growth. In addition, the chances of inaccurate test result is also hampering the markets growth.

The report broadly divides the global pregnancy detection kits market into: North America, Asia Pacific, Europe, Latin America, and the Middle East and Africa. Of these, North America is the largest market for pregnancy detection kits due to high government spending for quality healthcare and increased awareness for the utilization of pregnancy detection devices. The region is followed by Europe due to the high adoption of digital pregnancy test kits along with rising disposable incomes.

Asia Pacific is expected to emerge as a significant regional market due to the rising adoption of pregnancy detection kits in rural areas, increasing awareness about the benefits of early detection of pregnancy, growing population, and rising disposable income.

Latin America is emerging as a significant regional market due to the increasing awareness about the benefits of early detection of pregnancy and the availability of pregnancy testing kits at affordable prices. The Middle East and Africa regional segment will display a sluggish growth due to low awareness about the usage of pregnancy testing kit and its associated benefits.

Some top players in the global pregnancy detection kits market include Alere Inc., Procter & Gamble Co., Church & Dwight, SPD Swiss Precision Diagnostics, Germaine Laboratories, Piramal Enterprises, Cardinal Health, Abbott Laboratories, DCC plc, Prestige Brands Holdings, Quidel Corporation, Kent Pharmaceuticals, Nantong egens bio Technology Company, and Confirm Biosciences.

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Pregnancy Detection Kits Market with Worldwide Industry Analysis to … – LANews By Abhishek Budholiya (press release) (blog)